Table of Contents
Foreword, by Jill O’Donnell-Tormey
Acknowledgments
Introduction
SECTION I: CTLA-4
1. James Allison
2. Jedd Wolchok
3. Axel Hoos
SECTION II: PD-1
4. Tasuku Honjo
5. Gordon Freeman
6. Suzanne L. Topalian
SECTION III: Immune Surveillance
7. Robert Schreiber, Cancer Immunoediting
SECTION IV: Vaccines
8. Drew Pardoll
9. Elizabeth Jaffee
SECTION V: Foundational Discoveries, Proof of Concept
10. Ralph Steinman, Dendritic Cells
11. Tak Mak, T-Cell Receptor (TCR)
12. Philip Greenberg, Adoptive Cell Therapy (ACT)
13. Steven Rosenberg, Interleukin-2 (IL-2)
SECTION VI: Chimeric Antigen Receptor–T Cells (CAR-Ts)
14. Zelig Eshhar
15. Patrick Hwu
16. Carl June
17. Michel Sadelain
SECTION VII: Business at the Bench: One Protein, One Virus
18. Patrick Baeuerle, Bispecific Antibodies
19. Robert Coffin, Oncolytics
SECTION VIII: T Regulatory Cells (Tregs)
20. Shimon Sakaguchi
21. Jeff Bluestone
SECTION IX: Cells and Signals: Good and Bad
22. David Munn, Indoleamine 2,3-Dioxygenase (IDO) (Signal)
23. Dmitry Gabrilovich, Myeloid-Derived Suppressor Cells (MDSCs) (Cell)
24. Tom Gajewski, Stimulator of Interferon Genes (STING) (Signal)
25. Laurence Zitvogel, Microbiome (Cell)
Epilogue
Glossary
Index